HURLEY, LAURENCE H.: search on Z-Library

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1

Insight into the Complexity of the i-Motif and G-Quadruplex DNA Structures Formed in the KRAS Promoter and Subsequent Drug-Induced Gene Repression

Kaiser, Christine, Van Ert, Natalie, Agrawal, Prashansa, Chawla, Reena, Yang, Danzhou, Hurley, Laurence H

Journal:

Journal of the American Chemical Society

Year:

2017

Language:

english

File:

PDF, 8.89 MB

english, 2017

2

Quadruplex-Interactive Agents as Telomerase Inhibitors: Synthesis of Porphyrins and Structure−Activity Relationship for the Inhibition of Telomerase

Shi, Dong-Fang, Wheelhouse, Richard T., Sun, Daekyu, Hurley, Laurence H.

Journal:

Journal of Medicinal Chemistry

Year:

2001

Language:

english

File:

PDF, 442 KB

english, 2001

3

T ELOMERE I NHIBITION AND T ELOMERE D ISRUPTION AS P ROCESSES FOR D RUG T ARGETING

Rezler, Evonne M., Bearss, David J., Hurley, Laurence H.

Journal:

Annual Review of Pharmacology

Year:

2003

Language:

english

File:

PDF, 447 KB

english, 2003

4

THE NO-REFLOW PHENOMENON IN EXPERIMENTAL FREE FLAPS

MAY, JAMES W., CHAIT, LAURENCE A., OʼBRIEN, BERNARD M., HURLEY, JOHN V.

Journal:

Plastic & Reconstructive Surgery

Year:

1978

File:

PDF, 615 KB

1978

5

Drug Targeting of the c-MYC Promoter to Repress Gene Expression via a G-Quadruplex Silencer Element

Laurence H. Hurley, Daniel D. Von Hoff, Adam Siddiqui-Jain, Danzhou Yang

Journal:

Seminars in Oncology

Year:

2006

Language:

english

File:

PDF, 2.02 MB

english, 2006

6

The c- MYC NHE III 1 : Function and Regulation

González, Verónica, Hurley, Laurence H.

Journal:

Annual Review of Pharmacology

Year:

2010

Language:

english

File:

PDF, 885 KB

english, 2010

7

Sequence selectivity of DNA covalent modification

Warpehoski, Martha A., Hurley, Laurence H.

Journal:

Chemical Research in Toxicology

Year:

1988

Language:

english

File:

PDF, 4.21 MB

english, 1988

8

Solution Structure of a 2:1 Quindoline–c-MYC G-Quadruplex: Insights into G-Quadruplex-Interactive Small Molecule Drug Design

Dai, Jixun, Carver, Megan, Hurley, Laurence H., Yang, Danzhou

Journal:

Journal of the American Chemical Society

Year:

2011

Language:

english

File:

PDF, 3.89 MB

english, 2011

9

Pyrrolo[1,4]benzodiazepine antitumor antibiotics: relationship of DNA alkylation and sequence specificity to the biological activity of natural and synthetic compounds

Hurley, Laurence H., Reck, Teri, Thurston, David E., Langley, David R., Holden, Kenneth G., Hertzberg, Robert P., Hoover, John R. E., Gallagher, Gregory, Faucette, Leo F.

Journal:

Chemical Research in Toxicology

Year:

1988

Language:

english

File:

PDF, 2.49 MB

english, 1988

10

Pyrrolo[1,4]benzodiazepine antibiotics. Proposed structures and characteristics of the in vitro deoxyribonucleic acid adducts of anthramycin, tomaymycin, sibiromycin, and neothramycins A and B

Petrusek, Ruby L., Anderson, Gary L., Garner, Tim F., Fannin, Quinton L., Kaplan, David J., Zimmer, Stephen G., Hurley, Laurence H.

Journal:

Year:

1981

Language:

english

File:

PDF, 2.30 MB

english, 1981

11

Structure of the Biologically Relevant G-Quadruplex in The c-MYC Promoter

Yang, Danzhou, Hurley, Laurence H.

Journal:

Nucleosides Nucleotides & Nucleic Acids

Year:

2006

Language:

english

File:

PDF, 6.58 MB

english, 2006

12

The Dynamic Character of the G-Quadruplex Element in the c-MYC Promoter and Modification by TMPyP4

Seenisamy, Jeyaprakashnarayanan, Rezler, Evonne M., Powell, Tiffanie J., Tye, Denise, Gokhale, Vijay, Joshi, Chandana Sharma, Siddiqui-Jain, Adam, Hurley, Laurence H.

Journal:

Journal of the American Chemical Society

Year:

2004

Language:

english

File:

PDF, 329 KB

english, 2004

13

Reaction of CC-1065 and select synthetic analogs with DNA

Laurence H. Hurley, Chong-Soon Lee, J.Patrick McGovren, Martha A. Warpehoski, Mark A. Mitchell, Robert C. Kelly, Paul A. Aristoff

Journal:

Biochemical Pharmacology

Year:

1988

Language:

english

File:

PDF, 176 KB

english, 1988

14

Standardizing the Process for Developing Simulation-based Experiences: Initial Inquiry to Follow-up

Jacqueline J. Arnold, Laurence C. Torsher, Thomas E. Belda, Lisa M. Hurley, Christa Keehr, William F. Dunn

Journal:

Clinical Simulation in Nursing

Year:

2008

Language:

english

File:

PDF, 177 KB

english, 2008

15

Inhibition of Unwinding of G-Quadruplex Structures by Sgs1 Helicase in the Presence of N , N ‘-Bis[2-(1-piperidino)ethyl]-3,4,9,10-perylenetetracarboxylic Diimide, a G-Quadruplex-Interactive Ligand †

Han, Haiyong, Bennett, Richard J., Hurley, Laurence H.

Journal:

Year:

2000

Language:

english

File:

PDF, 99 KB

english, 2000

16

Interstrand cross-linking by bizelesin produces a Watson-Crick to Hoogsteen base-pairing transition region in d(CGTAATTACG)2

Seaman, Frederick C., Hurley, Laurence

Journal:

Year:

1993

Language:

english

File:

PDF, 2.04 MB

english, 1993

17

Evidence for the Formation of 2:2 Drug−Mg 2+ Dimers in Solution and for the Formation of Dimeric Drug Complexes on DNA from the DNA-Accelerated Photochemical Reaction of Antineoplastic Quinobenzoxazines

Yu, Hongtao, Hurley, Laurence H., Kerwin, Sean M.

Journal:

Journal of the American Chemical Society

Year:

1996

Language:

english

File:

PDF, 211 KB

english, 1996

18

The inefficiency of incisions of ecteinascidin 743–DNA adducts by the UvrABC nuclease and the unique structural feature of the DNA adducts can be used to explain the repair-dependent toxicities of this antitumor agent

Maha Zewail-Foote, Ven-Shun Li, Harold Kohn, David Bearss, Mary Guzman, Laurence H Hurley

Journal:

Chemistry & Biology

Year:

2001

Language:

english

File:

PDF, 1.15 MB

english, 2001

19

Correlation of DNA sequence specificity of anthramycin and tomaymycin with reaction kinetics and bending of DNA

Kizu, Ryoichi, Draves, Patricia H., Hurley, Laurence H.

Journal:

Year:

1993

Language:

english

File:

PDF, 2.70 MB

english, 1993

20

Molecular Basis for the DNA Sequence Specificity of the Pluramycins. A Novel Mechanism Involving Groove Interactions Transmitted through the Helix via Intercalation To Achieve Sequence Selectivity at the Covalent Bonding Step

Sun, Daekyu, Hansen, Mark, Hurley, Laurence

Journal:

Journal of the American Chemical Society

Year:

1995

Language:

english

File:

PDF, 4.77 MB

english, 1995

21

Evidence for the Presence of a Guanine Quadruplex Forming Region within a Polypurine Tract of the Hypoxia Inducible Factor 1α Promoter †

De Armond, Richard, Wood, Stacey, Sun, Daekyu, Hurley, Laurence H., Ebbinghaus, Scot W.

Journal:

Year:

2005

Language:

english

File:

PDF, 730 KB

english, 2005

22

Synthesis of Sequence-Selective C8-Linked Pyrrolo[2,1- c ][1,4]benzodiazepine DNA Interstrand Cross-Linking Agents

Thurston, David E., Bose, D. Subhas, Thompson, Andrew S., Howard, Philip W., Leoni, Alberto, Croker, Stephen J., Jenkins, Terrence C., Neidle, Stephen, Hartley, John A., Hurley, Laurence H.

Journal:

Journal of Organic Chemistry

Year:

1996

Language:

english

File:

PDF, 268 KB

english, 1996

23

Proof for the biosynthetic conversion of L-(indole-15N)tryptophan to (10-15N)anthramycin using (13C,15N) labelling in conjunction with 13C-NMR and mass spectral analysis.

OSTRANDER, JOHN M., HURLEY, LAURENCE H., MCINNES, A. GAVIN, SMITH, DONALD G., WALTER, JOHN A., WRIGHT, JEFFREY L. C.

Journal:

The Journal of Antibiotics

Year:

1980

Language:

english

File:

PDF, 2.39 MB

english, 1980

24

The 3′-End Region of the Human PDGFR-β Core Promoter Nuclease Hypersensitive Element Forms a Mixture of Two Unique End-Insertion G-Quadruplexes

Onel, Buket, Carver, Megan, Agrawal, Prashansa, Hurley, Laurence H., Yang, Danzhou

Journal:

Biochimica et Biophysica Acta (BBA) - General Subjects

Year:

2017

Language:

english

File:

PDF, 1.58 MB

english, 2017

25

In vitro activity of a G-quadruplex-stabilizing small molecule that synergizes with Navitoclax to induce cytotoxicity in acute myeloid leukemia cells

Montoya, Justin J., Turnidge, Megan A., Wai, Daniel H., Patel, Apurvi R., Lee, David W., Gokhale, Vijay, Hurley, Laurence H., Arceci, Robert J., Wetmore, Cynthia, Azorsa, David O.

Journal:

Year:

2019

File:

PDF, 2.12 MB

2019

26

DNA as a target for drug action

Laurence H. Hurley, F.Leslie Boyd

Journal:

Trends in Pharmacological Sciences

Year:

1988

Language:

english

File:

PDF, 941 KB

english, 1988

27

DNA sequence specificity of the pyrrolo[1,4]benzodiazepine antitumor antibiotics. Methidiumpropyl-EDTA-iron(II) footprinting analysis of DNA binding sites for anthramycin and related drugs

Hertzberg, Robert P., Hecht, Sidney M., Reynolds, Vincent L., Molineux, Ian J., Hurley, Laurence H.

Journal:

Year:

1986

Language:

english

File:

PDF, 4.55 MB

english, 1986

28

Effect of DNA Secondary Structure on Human Telomerase Activity †

Fletcher, Terace M., Sun, Daekyu, Salazar, Miguel, Hurley, Laurence H.

Journal:

Year:

1998

Language:

english

File:

PDF, 181 KB

english, 1998

29

Formation of Pseudosymmetrical G-Quadruplex and i-Motif Structures in the Proximal Promoter Region of the RET Oncogene

Guo, Kexiao, Pourpak, Alan, Beetz-Rogers, Kara, Gokhale, Vijay, Sun, Daekyu, Hurley, Laurence H.

Journal:

Journal of the American Chemical Society

Year:

2007

Language:

english

File:

PDF, 574 KB

english, 2007

30

Determination of the structural features of (+)-CC-1065 that are responsible for bending and winding of DNA

Lee, Chong Soon, Sun, Daekyu, Kizu, Ryoichi, Hurley, Laurence H.

Journal:

Chemical Research in Toxicology

Year:

1991

Language:

english

File:

PDF, 3.73 MB

english, 1991

31

Tertiary DNA Structure in the Single-Stranded hTERT Promoter Fragment Unfolds and Refolds by Parallel Pathways via Cooperative or Sequential Events

Yu, Zhongbo, Gaerig, Vanessa, Cui, Yunxi, Kang, HyunJin, Gokhale, Vijay, Zhao, Yuan, Hurley, Laurence H., Mao, Hanbin

Journal:

Journal of the American Chemical Society

Year:

2012

Language:

english

File:

PDF, 3.11 MB

english, 2012

32

A Direct and Nondestructive Approach To Determine the Folding Structure of the I-Motif DNA Secondary Structure by NMR

Dai, Jixun, Ambrus, Attila, Hurley, Laurence H., Yang, Danzhou

Journal:

Journal of the American Chemical Society

Year:

2009

Language:

english

File:

PDF, 760 KB

english, 2009

33

Molecular modeling and biophysical analysis of the c-MYC NHE-III1silencer element

Derek J. Cashman, Robert Buscaglia, Matthew W. Freyer, Jamie Dettler, Laurence H. Hurley, Edwin A. Lewis

Journal:

Journal of Molecular Modeling

Year:

2008

Language:

english

File:

PDF, 396 KB

english, 2008

34

Structure-activity relationships of (+)-CC-1065 analogs in the inhibition of helicase-catalyzed unwinding of duplex DNA

Sun, Daekyu, Hurley, Laurence H.

Journal:

Journal of Medicinal Chemistry

Year:

1992

Language:

english

File:

PDF, 5.46 MB

english, 1992

35

Formation of a Unique End-to-End Stacked Pair of G-Quadruplexes in the hTERT Core Promoter with Implications for Inhibition of Telomerase by G-Quadruplex-Interactive Ligands

Palumbo, SunMi L., Ebbinghaus, Scot W., Hurley, Laurence H.

Journal:

Journal of the American Chemical Society

Year:

2009

Language:

english

File:

PDF, 6.72 MB

english, 2009

36

Molecular Cloning of the Human Platelet-Derived Growth Factor Receptor β (PDGFR-β) Promoter and Drug Targeting of the G-Quadruplex-Forming Region To Repress PDGFR-β Expression

Qin, Yong, Fortin, Jessica S., Tye, Denise, Gleason-Guzman, Mary, Brooks, Tracy A., Hurley, Laurence H.

Journal:

Year:

2010

Language:

english

File:

PDF, 4.97 MB

english, 2010

37

Studies in the usnic acid series. VIII. The biodegradation of (+)-usnic acid by Mortierella isabellina

Kutney, James P., Baarschers, William H., Chin, Oscar, Ebizuka, Yutaka, Hurley, Laurence, Leman, Jeffrey D., Salisbury, Phillip J., Sanchez, Ignacio H., Yee, Trevor, Bandoni, Robert J.

Journal:

Canadian Journal of Chemistry

Year:

1977

Language:

english

File:

PDF, 357 KB

english, 1977

38

Molecular struggle for transcriptional control

Henderson, Douglas, Hurley, Laurence H.

Journal:

Nature Genetics

Year:

1995

File:

PDF, 510 KB

1995

39

G-quadruplex DNA: a potential target for anti-cancer drug design

Haiyong Han, Laurence H Hurley

Journal:

Trends in Pharmacological Sciences

Year:

2000

Language:

english

File:

PDF, 238 KB

english, 2000

40

Rational design of a highly efficient irreversible DNA interstrand cross-linking agent based on the pyrrolobenzodiazepine ring system

Bose, D. Subhas, Thompson, Andrew S., Ching, Jingshan, Hartley, John A., Berardini, Mark D., Jenkins, Terence C., Neidle, Stephen, Hurley, Laurence H., Thurston, David E.

Journal:

Journal of the American Chemical Society

Year:

1992

Language:

english

File:

PDF, 784 KB

english, 1992

41

Characterization of a 12-mer duplex d(GGCGGAGTTAGG).cntdot.d(CCTAACTCCGCC) containing a highly reactive (+)-CC-1065 sequence by proton and phosphorus-31 NMR, hydroxyl-radical footprinting, and NOESY restrained molecular dynamics calculations

Lin, Chin Hsiung, Hill, G. Craig, Hurley, Laurence H.

Journal:

Chemical Research in Toxicology

Year:

1992

Language:

english

File:

PDF, 2.56 MB

english, 1992

42

Cooperative Bending of the 21-Base-Pair Repeats of the SV40 Viral Early Promoter by Human Sp1

Sun, Daekyu, Hurley, Laurence H.

Journal:

Year:

1994

Language:

english

File:

PDF, 3.27 MB

english, 1994

43

DNA and its associated processes as targets for cancer therapy

Hurley, Laurence H.

Journal:

Nature Reviews Cancer

Year:

2002

Language:

english

File:

PDF, 573 KB

english, 2002

44

Interactions of TMPyP4 and TMPyP2 with Quadruplex DNA. Structural Basis for the Differential Effects on Telomerase Inhibition

Han, Frank Xiaoguang, Wheelhouse, Richard T., Hurley, Laurence H.

Journal:

Journal of the American Chemical Society

Year:

1999

Language:

english

File:

PDF, 242 KB

english, 1999

45

The Major G-Quadruplex Formed in the Human Platelet-Derived Growth Factor Receptor β Promoter Adopts a Novel Broken-Strand Structure in K + Solution

Chen, Yuwei, Agrawal, Prashansa, Brown, Robert V., Hatzakis, Emmanuel, Hurley, Laurence, Yang, Danzhou

Journal:

Journal of the American Chemical Society

Year:

2012

Language:

english

File:

PDF, 1.55 MB

english, 2012

46

Sequence specificity of DNA alkylation by the unnatural enantiomer of CC-1065 and its synthetic analogs

Hurley, Laurence H., Warpehoski, Martha A., Lee, Chong Soon, McGovren, J. Patrick, Scahill, Terrence A., Kelly, Robert C., Mitchell, Mark A., Wicnienski, Nancy A., Gebhard, Ilse

Journal:

Journal of the American Chemical Society

Year:

1990

Language:

english

File:

PDF, 4.93 MB

english, 1990

47

Pluramycins. Old Drugs Having Modern Friends in Structural Biology

Hansen, Mark R., Hurley, Laurence H.

Journal:

Accounts of Chemical Research

Year:

1996

Language:

english

File:

PDF, 622 KB

english, 1996

48

[Advances in DNA Sequence-Specific Agents] Volume 2 || Preface

Hurley, Laurence H.

Year:

1996

Language:

english

File:

PDF, 63 KB

english, 1996

49

TBP binding to the TATA box induces a specific downstream unwinding site that is targeted by pluramycin

Daekyu Sun, Laurence H. Hurley

Journal:

Chemistry & Biology

Year:

1995

Language:

english

File:

PDF, 7.34 MB

english, 1995

50

Bio-organic and Natural Products Chemistry Molecular Biology Workshop

Laurence H. Hurley, John Kozarich, Michael Rogers

Journal:

Pharmaceutical Research

Year:

1987

File:

PDF, 688 KB

1987

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